A good friend died in hospital in Vancouver BC. He was fully vaccinated and boosted. Prior to passing he was bed ridden for a month. The attending physician, when asked what had killed him, by my friend’s daughter replied, ADE. Was really surprised that the Dr had the stones to state that.
I’m no virologist or biologist. I wish someone would contrast, Original Antigenic Sin,
ADE and Pathogenic Priming to what’s been described in this article. Could really use a whiteboard session or simple explanation.
Also, I had read prior to the bioweapon rollout that they had never found a viable candidate for a coronavirus as all candidates resulted in ADE.
Certainly! Let's break down these complex immunological concepts into more digestible explanations:
**Antibody-Dependent Enhancement (ADE)**: Imagine you have a security system that's supposed to recognize intruders. ADE is like a glitch in the system where the security guards (antibodies) not only fail to recognize the intruder (virus) but also accidentally help them get inside the house (cells). This can make an infection worse because the virus gets an unintended assist from the body's own defenses¹.
**Original Antigenic Sin (OAS)**: This is the immune system's version of "first impressions last." When your immune system encounters a new version of a pathogen it has seen before, it might rely too much on its memory of the old enemy rather than adapting to the new one. It's like using an outdated map to navigate a city that has changed; you might miss some important new landmarks (viral features)².
**Pathogenic Priming**: This term is less commonly used in scientific literature but generally refers to a situation where a previous exposure to a pathogen (or vaccine) somehow makes subsequent infections more severe. It's as if the initial exposure sets a trap for the immune system, leading to a more dramatic response when encountering the pathogen again.
These phenomena are important because they can influence how our bodies respond to infections and vaccinations. They're particularly relevant in the context of diseases like COVID-19 and dengue fever, where the immune system's memory and reaction to previous exposures can affect the outcome of a new infection¹²³.
Absolutely, let's dive into the mechanisms of action for each concept:
**Antibody-Dependent Enhancement (ADE)**: Think of ADE as a case of mistaken identity. Normally, antibodies are like bouncers that block viruses from entering cells. But sometimes, they can get tricked. Instead of blocking the virus, they end up helping it bind to and enter cells more efficiently. It's like a bouncer accidentally letting in a disguised intruder because they recognize them as a regular, not realizing they're actually there to cause trouble³.
**Original Antigenic Sin (OAS)**: This is all about the immune system's memory being a bit too stubborn. When faced with a new but similar threat, the immune system might prefer to use the old playbook instead of writing a new one. It's like always using the first recipe you learned for a dish, even when there are new and better ingredients available. This can lead to a less effective response because the immune system is stuck in its ways, focusing on the first version of the pathogen it encountered².
**Pathogenic Priming**: This concept is a bit like setting a trap for yourself. The idea is that the immune system's first encounter with a pathogen or vaccine primes it to react in an exaggerated way the next time around. It's as if the immune system overreacts because it's been fooled once before, leading to a more severe response than necessary.
These mechanisms are crucial in understanding how our bodies fight off diseases and how vaccines are designed to help in that process. They highlight the delicate balance our immune system must maintain to protect us without causing additional harm¹²³.
Wow! Thank you Elliott.
A good friend died in hospital in Vancouver BC. He was fully vaccinated and boosted. Prior to passing he was bed ridden for a month. The attending physician, when asked what had killed him, by my friend’s daughter replied, ADE. Was really surprised that the Dr had the stones to state that.
I’m no virologist or biologist. I wish someone would contrast, Original Antigenic Sin,
ADE and Pathogenic Priming to what’s been described in this article. Could really use a whiteboard session or simple explanation.
Also, I had read prior to the bioweapon rollout that they had never found a viable candidate for a coronavirus as all candidates resulted in ADE.
Here's what MS Copilt GPT-4 came up with:
Certainly! Let's break down these complex immunological concepts into more digestible explanations:
**Antibody-Dependent Enhancement (ADE)**: Imagine you have a security system that's supposed to recognize intruders. ADE is like a glitch in the system where the security guards (antibodies) not only fail to recognize the intruder (virus) but also accidentally help them get inside the house (cells). This can make an infection worse because the virus gets an unintended assist from the body's own defenses¹.
**Original Antigenic Sin (OAS)**: This is the immune system's version of "first impressions last." When your immune system encounters a new version of a pathogen it has seen before, it might rely too much on its memory of the old enemy rather than adapting to the new one. It's like using an outdated map to navigate a city that has changed; you might miss some important new landmarks (viral features)².
**Pathogenic Priming**: This term is less commonly used in scientific literature but generally refers to a situation where a previous exposure to a pathogen (or vaccine) somehow makes subsequent infections more severe. It's as if the initial exposure sets a trap for the immune system, leading to a more dramatic response when encountering the pathogen again.
These phenomena are important because they can influence how our bodies respond to infections and vaccinations. They're particularly relevant in the context of diseases like COVID-19 and dengue fever, where the immune system's memory and reaction to previous exposures can affect the outcome of a new infection¹²³.
Source: Conversation with Bing, 3/25/2024
(1) Antibody Dependent Enhancement Due to Original Antigenic Sin and the .... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01120/full.
(2) Difference between original antigenic sin and antibody dependent .... https://www.reddit.com/r/Immunology/comments/4jj9fj/difference_between_original_antigenic_sin_and/.
(3) JCI - Impact of antigenic evolution and original antigenic sin on SARS .... https://www.jci.org/articles/view/162192.
(4) Original antigenic sin - Wikipedia. https://en.wikipedia.org/wiki/Original_antigenic_sin.
(5) undefined. https://doi.org/10.3389/fimmu.2020.01120.
asked for more detail:
Absolutely, let's dive into the mechanisms of action for each concept:
**Antibody-Dependent Enhancement (ADE)**: Think of ADE as a case of mistaken identity. Normally, antibodies are like bouncers that block viruses from entering cells. But sometimes, they can get tricked. Instead of blocking the virus, they end up helping it bind to and enter cells more efficiently. It's like a bouncer accidentally letting in a disguised intruder because they recognize them as a regular, not realizing they're actually there to cause trouble³.
**Original Antigenic Sin (OAS)**: This is all about the immune system's memory being a bit too stubborn. When faced with a new but similar threat, the immune system might prefer to use the old playbook instead of writing a new one. It's like always using the first recipe you learned for a dish, even when there are new and better ingredients available. This can lead to a less effective response because the immune system is stuck in its ways, focusing on the first version of the pathogen it encountered².
**Pathogenic Priming**: This concept is a bit like setting a trap for yourself. The idea is that the immune system's first encounter with a pathogen or vaccine primes it to react in an exaggerated way the next time around. It's as if the immune system overreacts because it's been fooled once before, leading to a more severe response than necessary.
These mechanisms are crucial in understanding how our bodies fight off diseases and how vaccines are designed to help in that process. They highlight the delicate balance our immune system must maintain to protect us without causing additional harm¹²³.
Source: Conversation with Bing, 3/25/2024
(1) A Review: Understanding Molecular Mechanisms of Antibody-Dependent .... https://www.mdpi.com/2076-393X/11/7/1240.
(2) JCI - Impact of antigenic evolution and original antigenic sin on SARS .... https://www.jci.org/articles/view/162192.
(3) Antibody Dependent Enhancement Due to Original Antigenic Sin and the .... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01120/full.
(4) A Review: Understanding Molecular Mechanisms of Antibody-Dependent .... https://mdpi-res.com/d_attachment/vaccines/vaccines-11-01240/article_deploy/vaccines-11-01240-v2.pdf?version=1689580517.
(5) Neutralizing Antibodies and Antibody-Dependent Enhancement in COVID-19 .... https://link.springer.com/article/10.1007/s41745-021-00268-8.
(6) undefined. https://doi.org/10.3389/fimmu.2020.01120.
lots of references! have fun!